Decriminalize Sex Work (DSW), the principal branch of the organization, works to improve public attitudes toward sex work and the decriminalization of prostitution. DSW, a 501(c)(3) nonprofit, was founded on June 22, 2018.

The Campaign to Decriminalize Sex Work (CDSW) is the lobbying branch of the organization, focusing most of its resources on lobbying state legislatures to change state laws. This branch of the organization was founded on December 21, 2018, and is a 501(c)(4) organization.

DSW and CDSW operate collaboratively out of offices in Austin, Brooklyn, and Washington, D.C. Both branches of this organization are intended to supplement — not supplant — the good work that so many organizations have been doing for years to decriminalize sex work in the United States.